Table 2.
Phagocytic and oxidative burst activity of neutrophils, level of soluble form of adhesive molecules and TNFα in liver cirrhosis patients (mean±SD)
|
Liver cirrhosis |
Healthy | |||
| Total | Child–Pugh B | Child–Pugh C | ||
| Oxidative burst | ||||
| Percentage of neutrophils with oxidative burst after PMA stimulation (%) | 98.3±1.2 | 98.4±1.5 | 98.2±1.6 | 98.8±2.8 |
| MIF oxidative burst after PMA stimulation | 42.7±14.6b | 44.3±10.1b | 41.1±12.6b | 50.2±13.3 |
| Percentage of neutrophils with oxidative burst after E. coli stimulation (%) | 94.0±4.8 | 93.0±4.1 | 94.0±3.8 | 92.2±3.7 |
| MIF oxidative burst after E. coli stimulation | 24.7±7.1b | 25.1±8.1b | 22.2±5.1b | 29.7±6.6 |
| Phagocytic activity | ||||
| Percentage of neutrophils phagocytizing of E. coli | 93.0±3.3 | 92.9±4.3 | 93.8±2.3 | 92.5±4.3 |
| MIF phagocytosis E. coli | 20.0±3.9 | 19.8±4.1 | 21.0±2.8 | 19.0±5.8 |
| Soluble form of adhesion molecules and TNFα | ||||
| sICAM-1 (ng/mL) | 852±331b | 788±343b | 892±293b | 254±74 |
| sVCAM-1 (ng/mL) | 2 937±1 591b | 2 637±1 291b | 3 297±1 490b | 510±248 |
| sP-selectin (ng/mL) | 101±180b | 98±140b | 104±162b | 124±58 |
| sE-selectin (ng/mL) | 136±89b | 120±68b | 148±58b | 49±21 |
| sL-selectin (ng/mL) | 1 209±364 | 1 206±314 | 1 211±344 | 1 209±291 |
| TNFα (pg/mL) | 2.94±1.43b | 2.64±1.33b | 2.99±1.02b | 1.58±0.22 |
b
P<0.01 vs healthy subjects (Mann–Whitney U test).