Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Increased eRMS incidence and decreased age of onset in cardiotoxin-treated p53-deficient mice. Muscle regeneration was induced by treatment of wild-type (Trp53+/+) and p53-deficient (Trp53−/−) mice with cardiotoxin (Ctx). Ctx-treated Trp53−/− mice showed robust induction of embryonal rhabdomyosarcoma (eRMS) by 5 months of age. n = 50 Trp53+/+ (wild-type), 12 Ctx-Trp53+/+ (cardiotoxin-injected), 22 Trp53−/−, 10 Ctx-Trp53−/− (cardiotoxin-injected).
