Fig. 6.

Effect of CLIC4 on the endoplasmic reticulum-stress apoptotic pathway. Representative images (a) and summarized data (b–e) showing the expression levels of CLIC4 (a), CHOP (a, b–c) and active caspase 4 (a, d–e). The HN4 cells were transfected with CLIC4 (+,CLIC4 siRNA) or scrambled (−, Con) siRNA, and treated with (+, +ATP) or without (−, −ATP) 100 μmol/L ATP for 3 h. β-Tubulin was used as a loading control. Values are shown as the mean ± SE. n = 3. *P < 0.05. vs. the control (Con) group