Table 2.
Gene Ontology (GO) categories significantly overrepresented in CNVRs
| GO categoriesa | gene number in CNVR | expected gene numberb | P valuec | |
|---|---|---|---|---|
| Biological | response to stimulus | 124 | 61.18 | 8.14E-12 |
| Process | cellular defense response | 51 | 15.71 | 1.25E-10 |
| immune system process | 120 | 61.91 | 4.61E-10 | |
| hemopoiesis | 23 | 5.57 | 5.45E-06 | |
| immune response | 51 | 22.36 | 1.83E-05 | |
| B cell mediated immunity | 28 | 8.8 | 3.71E-05 | |
| extracellular transport | 18 | 4.94 | 1.01E-03 | |
| response to interferon-gamma | 14 | 3.1 | 1.14E-03 | |
| Cellular | immunoglobulin complex | 20 | 0.98 | 4.32E-18 |
| Component | protein complex | 48 | 17.26 | 2.21E-08 |
| macromolecular complex | 50 | 21.76 | 4.03E-06 | |
| heterotrimeric G-protein complex | 8 | 1.24 | 2.23E-03 | |
| MHC protein complex | 10 | 2.03 | 2.53E-03 | |
| Molecular | antigen binding | 20 | 0.98 | 1.35E-17 |
| Function | ATPase activity, coupled to transmembrane movement of substances | 9 | 1.46 | 3.40E-03 |
aList of GO categories associated with overrepresentation of genes in the CNVRs (P < 0.05)
bEnsembl gene list of 19,799 Bos taurus genes compared to the list of 717 genes in the CNVRs using PANTHER 9.0
cBonferroni-corrected P value