Table 3.
Distribution of MLH1, MGMT, DAPK-1 methylation according to tumor site and pathological characteristics
| MLH1 M/U | MGMT M/U | DAPK-1 M/U | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Tumor histological parameters | Stomach upper-third cancerous tissue | Stomach middle-third cancerous tissue | Stomach lower-third cancerous tissue | Stomach upper-third cancerous tissue | Stomach middle-third cancerous tissue | Stomach lower-third cancerous tissue | Stomach upper-third cancerous tissue | Stomach middle-third cancerous tissue | Stomach lower-third cancerous tissue |
| Intestinal type | 0/3 | 6/16 | 7/10 | 1/2 | 5/17 | 8/11 | 3/0 | 12/10 | 10/7 |
| Diffuse type | 1/5 | 3/14 | 8/8 | 1/5 | 7/10 | 11/5 | 1/5 | 7/10 | 7/9 |
| p value | 0.45 | 0.48 | 0.61 | 0.57 | 0.22 | 0.21 | 0.02 | 0.41 | 0.39 |
| T1 | 0/1 | 1/2 | 2/4 | 0/1 | 1/2 | 4/2 | 1/0 | 2/1 | 4/2 |
| T2 | 0/2 | 2/2 | 2/3 | 0/2 | 1/3 | 3/2 | 1/1 | 0/4 | 3/2 |
| T3 | 0/2 | 5/11 | 8/9 | 1/1 | 4/12 | 10/7 | 1/1 | 6/10 | 7/10 |
| T4 | 1/3 | 1/15 | 3/2 | 1/3 | 6/10 | 2/3 | 1/3 | 11/5 | 3/2 |
| p value | 0.7 | 0.17 | 0.83 | 0.62 | 0.88 | 0.84 | 0.59 | 0.06 | 0.67 |
| N0 | 0/4 | 5/9 | 6/4 | 2/2 | 4/10 | 5/5 | 3/1 | 4/10 | 6/4 |
| N1 | 0/2 | 2/4 | 3/5 | 0/2 | 2/4 | 5/3 | 0/2 | 2/4 | 4/4 |
| N2 | 0/2 | 1/6 | 3/2 | 0/2 | 1/6 | 3/2 | 1/1 | 2/5 | 1/4 |
| N3 | 1/0 | 1/11 | 3/7 | 0/1 | 5/7 | 6/4 | 0/1 | 11/1 | 6/4 |
| p value | 0.29 | 0.33 | 0.48 | 0.36 | 0.66 | 0.95 | 0.27 | 0.01 | 0.46 |
M methylated allele, U unmethylated allele