TABLE 1.
Baseline characteristics of the discovery and replication studies
| Characteristics | Discovery (n = 8,223) | Replication (n = 1,735) |
| Age (years) | 51.86 ± 8.8 | 44.1 ± 13.0 |
| BMI (kg/m2) | 24.54 ± 3.12 | 23.68 ± 3.28 |
| TG (mmol/l) | 1.80 ± 1.15 | 1.30 ± 0.89 |
| HDL-C (mmol/l) | 0.50 ± 0.10 | 0.57 ± 0.14 |
| LDL-C (mmol/l) | 1.31 ± 0.37 | 1.25 ± 0.35 |
| TC (mmol/l) | 2.24 ± 0.41 | 2.14 ± 0.40 |
| Glucose (mmol/l) | 0.99 ± 0.25 | 1.05 ± 0.21 |
| Gender, Male, n (%) | 3,858 (46.9) | 672 (38.7) |
| Cigarette smoking | ||
| Never | 4,818 (59.4) | 1,219 (71.3) |
| Ex-smoker | 1,224 (15.1) | 180 (10.5) |
| Current smoker | 2,075 (25.6) | 310 (18.1) |
| Diabetes | ||
| Yes | 613 (6.93) | 87 (4.68) |
| No | 8,229 (93.1) | 1,770 (95.3) |
| Lipid-altering medication | ||
| Yes | 40 (0.45) | 40 (2.15) |
| No | 8,802 (99.5) | 1,817 (97.8) |
The lipid values were calculated after excluding individuals who had a diagnosis of diabetes or were using lipid-lowering agents. Values shown are numbers (frequencies) for categorical variables and mean ± SD for continuous variables. HDL-C, HDL cholesterol; LDL-C, LDL cholesterol; TC, total cholesterol.