TABLE 3.

Haplotype association of five significant SNPs from BUD13-ZNF259-A5 in proximity to the 11q23.3 region with plasma TG level

Haplotype	Haplotype frequency	β (95% CI)	P
ACCAC	0.079	0.17 (0.14 to 0.20)	1.1E-10−5
ACGCC	0.218	0.10 (0.08 to 0.12)	1.4E-10−5
ACCCT	0.276	Reference	Reference
CCCCT	0.202	−0.05 (−0.08 to 0.03)	1.5E-10−5
ATCCT	0.224	−0.05 (−0.07 to 0.03)	1.0E-10−5

The “haplo.glm” function implemented in the “haplo.stats” R package was used to calculate the coefficient β and P values for each haplotype compared with the reference haplotype, which was set as the ACCCT haplotype. The same covariates used for genotype analysis were applied in haplotype analysis. Haplotype analysis was performed in 8,223 unrelated individuals in the KARE. Alleles in haplotypes were presented in order of polymorphisms rs11216126/BUD13, rs964184/ZNF259, rs603446/ZNF259, rs2075291/ApoA5, and rs651821/ApoA5. CI, confidence interval. Changes of nucleotides are underlined.