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. Author manuscript; available in PMC: 2016 Jan 26.
Published in final edited form as: N Engl J Med. 2013 Nov 28;369(22):2105–2114. doi: 10.1056/NEJMoa1304603

Figure 1. Chromosomal Alterations in Nodules Identified by Means of Single-Nucleotide Polymorphism (SNP) Arrays.

Figure 1

Panel A shows the number of patients with corticotropin-independent macronodular adrenal hyperplasia who had a chromosomal alteration (gain, loss, or copy-neutral loss of heterozygosity) in at least one nodule. The most common event, the copy-neutral loss of heterozygosity in 16p, was detected in 7 of 26 patients. Panel B shows chromosome 16 from a nodule obtained from Patient 5 with a copy-neutral loss of heterozygosity in 16p. The upper part of the panel shows genotypes of the SNPs expressed as the B allele frequency. The lower part of the panel shows the DNA copy number expressed on a base-2 log scale (log ratio), with the red line corresponding to two copies of DNA.