Table 1.
Characteristics of the included studies by CD44 mRNA expression in the meta-analysis
| References | Year | Country or area | Duration (months) | Stage | Quality score | Detection | Cutoff values | Patients with CD44 overexpression (total number) |
|---|---|---|---|---|---|---|---|---|
| Desmedt et al21 | 2007 | Canada | NA | NA | 8 | Microarray | Median expression: 9.34 | 99 (198) |
| Heikkinen et al27 | 2011 | Finland | 36 | NA | 8 | Microarray | Median expression: 11.05 | 92 (183) |
| Terunuma et al28 | 2014 | USA | NA | I–III | 9 | Microarray | Median expression: 11.12 | 31 (61) |
| Sircoulomb et al29 | 2010 | France | 240 | NA | 7 | Microarray | Median expression: 7.60 | 26 (51) |
| Clarke et al30 | 2013 | Canada | 180 | NA | 8 | Microarray | Median expression: NA | 39 (77) |
| Ma et al31 | 2009 | USA | 36 | NA | 7 | Microarray | Median expression: 2.33 | 19 (38) |
| Hatzis et al32 | 2011 | USA | 120 | I–IV | 9 | Microarray | Median expression: 9.63 | 254 (508) |
| Tofigh et al33 | 2014 | Canada | NA | I–IV | 8 | Microarray | Median expression: 11.63 | 161 (321) |
| Kao et al34 | 2011 | Taiwan | 156 | I–IV | 9 | Microarray | Median expression: 8.06 | 164 (327) |
| Minn et al35 | 2005 | USA | NA | NA | 8 | Microarray | Median expression: 1,674.60 | 50 (99) |
| Desmedt et al36 | 2011 | Canada | NA | NA | 8 | Microarray | Median expression: 2.94 | 61 (120) |
| Schmidt et al37 | 2008 | Germany | 120 | NA | 9 | Microarray | Median expression: 1,595 | 100 (200) |
| Nagalla et al38 | 2013 | USA | NA | NA | 8 | Microarray | Median expression: 10.33 | 70 (139) |
| Loi et al39 | 2007 | Canada | NA | NA | 9 | Microarray | Median expression: 6.52 | 164 (327) |
| Dedeurwaerder et al40 | 2011 | Canada | NA | NA | 8 | Microarray | Median expression: 7.18 | 45 (90) |
| Miller et al41 | 2005 | Singapore | NA | NA | 9 | Microarray | Median expression: 8.04 | 126 (251) |
| Symmans et al42 | 2010 | USA | NA | NA | 9 | Microarray | Median expression: 10.78 | 149 (298) |
| Pawitan et al43 | 2005 | Sweden | 24 | NA | 8 | Microarray | Median expression: 7.04 | 80 (159) |
| Wang et al44 | 2005 | USA | 180 | NA | 9 | Microarray | Median expression: 1,285.15 | 143 (286) |
| Hu et al45 | 2009 | USA | NA | NA | 7 | Microarray | Median expression: NA | 40 (80) |
| Hennessy et al46 | 2009 | USA | NA | NA | 9 | Microarray | Median expression: NA | 47 (94) |
| Bild et al47 | 2006 | USA | NA | NA | 9 | Microarray | Median expression: 62.00 | 80 (158) |
| Minn et al48 | 2007 | USA | NA | NA | 7 | Microarray | Median expression: 1,636.50 | 29 (58) |
Abbreviations: CD44, cluster of differentiation 44; NA, not available.