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. Author manuscript; available in PMC: 2016 Jan 26.
Published in final edited form as: Cancer Discov. 2015 Apr 20;5(5):475–487. doi: 10.1158/2159-8290.CD-15-0011

Figure 1. The intrinsic apoptotic pathway is regulated by BCL-2 family proteins at the level of the mitochondria.

Figure 1

Multiple cellular stressors modulate the expression levels of pro- and anti-apoptotic BCL-2 family proteins (red and green respectively), leading to the activation of BAX and/or BAK and mitochondrial depolarization.