Figure 1.

Tissue‐specific variations of Cln1 mRNA level in Cln1 ^R151X mice. Endogenous Cln1 mRNA levels were measured by quantitative real‐time PCR in the brain (cerebellum, cortex, striatum/thalamus, brainstem) and peripheral tissues (liver, heart, lung, kidney, spleen, stomach, intestine, muscle, testes) from 5‐month‐old wild‐type (white bars) and Cln1 ^R151X (grey bars) male mice. The relative expression of Cln1 was normalized with four reference genes (B2m, Gapdh, Gusb, Hgprt). Columns and bars represent mean ± S.E.M. (three wild‐type and three Cln1 ^R151X mice; four technical replicates were used for each mouse).