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. 2015 Nov 27;20(2):313–322. doi: 10.1111/jcmm.12724

Figure 3.

Figure 3

miR‐124 affects the Notch signalling pathway by targeting JAG1. (A) Overexpression of miR‐124 caused significant reduction in the expressions of the Notch‐1 ligand (JAG‐1), cleaved Notch‐1 (NICD), and Notch‐1 target genes HES‐1 and HES‐5 in both SGC‐7901 and BGC‐823 cells. (B) GES‐1 cells were transfected with miR‐124 inhibitors and the miR‐124 expression was determined using real‐time PCR. (C) Transfection of miR‐124 inhibitors up‐regulated the expressions of JAG1, NICD, HES1 and HES5 in GES‐1 cells.