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. 2015 Dec 9;20(2):195–203. doi: 10.1111/jcmm.12723

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© 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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The mechanisms related to the role of stem cells in diabetic liver injury. Stem cell treatment for diabetic liver injury contributes to the improvement of liver function and histology, for example, embryonic stem cells (ESCs), mesenchymal stem cells (MSCs), induced pluripotent stem cells (iPScs) and hepatic oval cells. The underlying mechanisms of this action may include reducing hyperglycaemia, differentiating into β‐cells and hepatocytes, relieving insulin resistance (IR), reducing lipid accumulation and anti‐apoptosis, etc.