Table 2.
Tertiary structures of food, venom, and contact allergens
| Allergen | Species of origin | Function/structure | X-ray crystal structure | NMR structure | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ingested (food) | ||||||||||||||
| “Act c 1” | Actinidia chinensis | Cysteine protease (Act d 1-homolog) |
2ACT | 1AEC | ||||||||||
| Act c 5 | A. chinensis | Kiwellin | 4PMK | |||||||||||
| Act d 2 | A. deliciosa | Thaumatin-like protein | 4BCT | |||||||||||
| Act d 11 | A. deliciosa | Kirola | 4IGV | 4IHR | 4IGW | 4IGX | 4IGY | 4IH0 | 4IH2 | |||||
| Ani s 5 | Anisakis simplex | SXP/RAL-2 protein | 2MAR | |||||||||||
| Api g 1 | Apium graveolens | Pathogenesis related protein (PR-10) |
2BK0 | |||||||||||
| Ara h 1 | Arachis hypogaea | Cupin (Vicillin-type, 7S globulin) |
3S7E | 3S7I | 3SMH | |||||||||
| Arah 2 | A. hypogaea | Conglutin (2S albumin) | 3OB4 | |||||||||||
| Ara h 3 | A. hypogaea | Cupin (11S globulin, Glycinin) | 3C3V | |||||||||||
| Ara h 5 | A. hypogaea | Profilin | 4ESP | |||||||||||
| Ara h 6 | A. hypogaea | Conglutin (2S albumin) | 1W2Q | |||||||||||
| Ara h 8 | A. hypogaea | Pathogenesis related protein (PR-10) |
4MAP | 4MA6 | 4M9W | 4M9B | ||||||||
| Ber e 1 | Bertholletia excelsa | 2S sulfur-rich seed storage albumin |
2LVF | |||||||||||
| Bos d 4 | Bos domesticus | Alpha-lactalbumin | 1F6R | 1F6S | 2G4N | 1HFZ | 1HFX | 1HFY | ||||||
| Bos d 5 | B. domesticus | Beta-lactoglobulin | 1GX8 | 1GX9 | 1GXA | 2AKQ | 1BSO | 1UZ2 (m) | 2R56a | |||||
| Bos d 6 | B. domesticus | Serum albumin | 3V03 | 4F5S | 4JK4 | |||||||||
| Bra n 1 | Brassica napus | 2S seed storage albumin | 1PNB | |||||||||||
| Cyp c 1 | Cyprinus carpio | Carp beta-parvalbumin | 4CPV | 5CPV | ||||||||||
| Dau c 1 | Daucus carota | Pathogenesis-related protein (PR-10) |
2WQL | |||||||||||
| Fra a 1 | Fragaria ananassa | Pathogenesis-related protein (PR-10) |
2LPX | |||||||||||
| Gad m 1 | Gadus morhua | Cod beta-parvalbumin | 2MBX | |||||||||||
| Gal d 2 | Gallus domesticus | Ovalbumin | 1JTI(m) | 1OVA | lUHG(m) | |||||||||
| Gal d 3 | G. domesticus | Ovotransferrin | 1RYX | 2D3I | 1OVT | 1AIV | 1TFA | 1IEJ | 1N04 | |||||
| Gal d 4 | G. domesticus | Lysozymeb | 1LYZ | lH6M(m) | 1YQVa | 1FDLa | 1MLCa | 3HFMa | 2A2Ya | 1DQJa | 1GXV | 1GXX | ||
| Gly m 4 | Glycine max | Pathogenesis-related protein (PR-10) |
2K7H | |||||||||||
| Gly m 5 | G. max | Beta-conglycinin (vicilin, 7S globulin) |
1IPJ | 1IPK | 1UIJ(m) | |||||||||
| Gly m 6 | G. max | Glycinin (legumin 11S globulin) |
1FXZ | 1OD5 | 2D5H | 2D5F | ||||||||
| Mal d 2 | Malus domestica | Thaumatin-like protein | 3ZS3 | |||||||||||
| Mus a 4 | Musa acuminata | Thaumatin-like protein | 1Z3Q | |||||||||||
| Mus a 5 | M. acuminata | Beta-1,3-glucanase | 2CYG | |||||||||||
| Pis s 1 | Pisum sativum | Legumin 11S globulin | 1PNB | 3KSC | ||||||||||
| Pru av 1 | Primus avium | Pathogenesis-related protein (PR-10) |
1H2O (m) | 1E09 | ||||||||||
| Pru av 2 | P. avium | Thaumatin-like protein | 2AHN | |||||||||||
| Pru du 6 | Primus dulcis | Amandin, 11S globulin 1 egumin-like protein |
3FZ3 | |||||||||||
| Pru p 3 | Prunus persica | Non-specific lipid transfer protein |
2ALG | 2B5S | ||||||||||
| Ric c 1 | Ricinus communis | 2S albumin storage protein | 1PSY | |||||||||||
| Tri a 14 | Triticum aestivum | Non-specific lipid transfer protein |
1BWO | 1CZ2 | 1GH1 | |||||||||
| Tria a 18 | T. aestivum | Agglutinin isolectin-1 | 4AML | 2X3T | 2UVO | 2CWG | 1WGC | 2WGC | 7WGA | 9WGA | ||||
| Vig r 6 | Vigna radiata | Cytokinin-specific binding protein (CSBP), Bet v 1 family member |
2FLH | 3C0V | ||||||||||
| Zea m 14 | Zea mays | Non-specific lipid ransfer protein |
1FK0 | 1FK1 | 1FK2 | 1FK3 | 1FK4 | 1FK5 | 1FK6 | 1FK7 | 1MZL | 1MZM | 1AFH | |
| Injected | ||||||||||||||
| Aed a 2 | Aedes aegypti | Salivary antigen | 3DXL | 3DY9 | 3DYE | 3DZT | ||||||||
| Api m 1 | Apis mellifera | Phospholipase A2 | 1POC | |||||||||||
| Api m 2 | A. mellifera | Hyaluronidase | 1FCQ | 1FCU | 1FCV | 2J88a | ||||||||
| Api m 4 | A. mellifera | Melittin | 2MLT | 1BH1 (m) | ||||||||||
| Arg r 1 | Argas reflexus | Histamine-binding lipocalin |
2X45 | 2X46 | ||||||||||
| Sol i 2 | Solenopsis invicta | Transport of hydrophobic ligands |
2YGU | |||||||||||
| Sol i 3 | S. invicta | Ves v 5-like | 2VZN | |||||||||||
| Ves v 2 | Vespula vulgaris | Hyaluronidase | 2ATM | |||||||||||
| Ves v 5 | V. vulgaris | Antigen 5 | 1QNX | |||||||||||
| Through skin | ||||||||||||||
| Mala s 1 |
Malassezia
sympodialis |
Beta-propeller fold | 2P9W | |||||||||||
| Mala s 6 | M. sympodialis | Cyclophilin | 2CFE | |||||||||||
| Mala s 13 | M. sympodialis | Thioredoxin | 2J23 | |||||||||||
The codes refer to the structure of molecules that are not necessarily the same polymorphism reported in the WHO/IUIS Allergen Nomenclature database.
(m) modified or mutated molecule
a
Allergen in complex with an antibody fragment
b
Structures selected from multiple PDB entries (>540 for hen egg lysozyme)