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. 2014 Sep 22;83(1):49–63. doi: 10.3797/scipharm.1407-14

Sch. 4.

Sch. 4

Synthetic scheme of lopinavir carboxymethyl analog 8. Reagents and conditions: (a) acetic anhydride, sulfuric acid; yield: 77%; (b) aluminium chloride, carbon disulfide, 120°C; yield: 81%; (c) chloroacetic acid, NaOH, water; yield: 70%; (d) morpholin, sulphur, NaOH; yield; 48%; (f) 5, thionyl chloride, dichloromethane, NaHCO3, water; yield; 38%