Sch. 4.
Synthetic scheme of lopinavir carboxymethyl analog 8. Reagents and conditions: (a) acetic anhydride, sulfuric acid; yield: 77%; (b) aluminium chloride, carbon disulfide, 120°C; yield: 81%; (c) chloroacetic acid, NaOH, water; yield: 70%; (d) morpholin, sulphur, NaOH; yield; 48%; (f) 5, thionyl chloride, dichloromethane, NaHCO3, water; yield; 38%