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. 2014 Sep 22;83(1):49–63. doi: 10.3797/scipharm.1407-14

Sch. 5.

Sch. 5

Synthetic scheme of lopinavir diamide impurity 9. Reagents and conditions: (a) ammonium formate, palladium on charcoal, methanol; yield: 100%; (b) (2,6-dimethylphenoxy)acetic acid, sodium bicarbonate; yield: 41%