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. 2014 Sep 30;83(1):143–158. doi: 10.3797/scipharm.1408-04

Fig. 4.

Fig. 4

Histopathological changes in mice livers after methimazole administration in normal and/or enzyme-induced animals. Haematoxylin and eosin (H&E) staining. A: control (vehicle-treated), B: +methimazole (200 mg/kg), C: enzyme-induced animals + methimazole (200 mg/kg), D: methimazole + taurine (1 g/kg), E: methimazole + NAC (300 mg/kg), F: enzyme-induced + methimazole (200 mg/kg) + taurine (1 g/kg), G: enzyme-induced + methimazole (200 mg/kg) + NAC (300 mg/kg). Methimazole administration caused sinusoidal congestion and slight inflammatory cell infiltration in mice livers (B). When enzyme-induced animals were treated with methimazole, liver necrosis, inflammation, and hemorrhage occurred (C). Administration of taurine (D & F) and/or NAC (E & G), effectively alleviated methimazole-induced histopathological changes in the liver in both intact and/or enzyme-induced animals.