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. 2016 Jan 26;10(1):e0004401. doi: 10.1371/journal.pntd.0004401

Table 1. Targets selected for yeast-based screens.

Target protein Brugia malayi Wuchereria bancrofti Homo sapiens Functions Cognate yeast gene
N-myristoyltransferase (NMT) Bm1_22900 WUBG_03313 O60551 Covalent attachment of myristic acid to the N-terminal glycine residue of several proteins, cellular growth and signal transduction NMT1
phosphoglycerate kinase (PGK) Bm1_01925 WUBG_03621 P00558 Glycolysis, energy metabolism PGK1
triose-phosphate isomerase (TPI) Bm1_29130 WUBG_07449 P60174 Glycolysis, energy metabolism TPI1
adenosyl homocysteinase Bm1_48165 WUBG_05842 P23526 Cellular lipid homoeostasis SAH1
Inorganic pyrophosphatase Bm1_16955 WUBG_14547 Q15181 Rapid exchange of oxygen from Pi with water IPP1
Phospho mannomutase Bm1_38705 WUBG_05311 O15305 Folding and glycosylation of secretory proteins SEC53
thymidylate synthase Bm1_33465 WUBG_07963 P04818 Biosynthesis of pyrimidine deoxyribonucleotides CDC21
lysyl-tRNA synthetase Bm1_16500 WUBG_09456 Q15046 Protein synthesis KRS1
adenylosuccinate lyase Bm1_11585 WUBG_03558 P30566 Purine nucleotide biosynthesis ADE13
diphospho mevalonate decarboxylase Bm1_42945 WUBG_07413 P53602 Biosynthesis of isoprenoids and sterols MVD1
ribose-5-phosphate isomerase Bm1_57600 WUBG_03052 P49247 Pentose phosphate pathway RKI1
thymidylate kinase Bm1_23075 WUBG_02750 P23919 Biosynthesis of pyrimidine deoxyribonucleotides CDC8
deoxyhypusine synthase Bm1_16300 WUBG_02450 P49366 Hypusine biosynthesis DYS1
very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase Bm1_32340 WUBG_04779 Q6Y1H2 Sphingolipid biosynthesis and protein trafficking PHS1
CDP-alcohol phosphatidyl transferase Bm1_49000 WUBG_00951 O14735 Biosynthesis of phosphatidylinositol (glycolipid anchors for some of the plasma membrane proteins) PIS1