Table 3.
Differences in Abundance of Taxa at Different Levels
| Mucosal Microbiota in Health and Constipation | ||||
|---|---|---|---|---|
| Taxon | Mean Abundance in Healthy Controls | Mean Abundance in Constipated Patients | P value | FDR- adjusted P value |
| Phyla | ||||
| Bacteroidetes | 0.39 | 0.60 | .04 | .20 |
| Family | ||||
| Bacteroidetes;Flavobacteriaceae | 0.00001 | 0.07 | .001 | .01 |
| Bacteroidetes;Odoribacteraceae | 0.01 | 0.0001 | .001 | .01 |
| Proteobacteria;Caulobacteraceae | 0.001 | 0.002 | .005 | .04 |
| Proteobacteria;Comamonadaceae | 0.13 | 0.002 | .001 | .01 |
| Genus | ||||
| Bacteroidetes;Flavobacterium | 0.00001 | 0.07 | .001 | .01 |
| Bacteroidetes;Odoribacter | 0.01 | 0.00001 | .002 | .02 |
| Proteobacteria;Comamonas | 0.002 | 0.000002 | .008 | .06 |
| Proteobacteria;Delftia | 0.09 | 0.001 | .001 | .01 |
| Proteobacteria;Mycoplana | 0.000001 | 0.002 | .001 | .01 |
| By Boruta feature selection | ||||
| Firmicutes;Faecalibacterium | 0.08 | 0.09 | NA | NA |
| Proteobacteria;Agrobacterium | 0.05 | 0.02 | NA | NA |
| Proteobacteria;Pseudomonas | 0.005 | 0.006 | NA | NA |
| Correlation Between Stool Microbiota and Colonic Transit | ||||
| Taxon | Spearman’s correlation coefficient | P value | FDR- adjusted P value | |
| Phylum | ||||
| Actinobacteria | 0.23 | .02 | .12 | |
| Family | ||||
| Actinobacteria;Coriobacteriaceae | 0.28 | .04 | .32 | |
| Firmicutes;Veillonellaceae | 0.18 | .01 | .30 | |
| Genus | ||||
| Firmicutes;Lactococcus | 0.44 | .01 | .33 | |
| Firmicutes;Roseburia | 0.34 | .01 | .33 | |
| By Boruta feature selection | ||||
| Bacteroidetes;Bacteroides | −0.20 | NA | NA | |
| Firmicutes;Coprococcus | 0.41 | NA | NA | |
| Firmicutes;Faecalibacterium | 0.36 | NA | NA | |
| Bacteroidetes;Butyricimonas | −0.12 | NA | NA | |
| Correlation Between Stool Microbiota and Breath Methane Concentration | ||||
| Taxon | Spearman’s correlation coefficient | P value | FDR- adjusted P value | |
| Phylum | ||||
| Proteobacteria | −0.21 | .006 | .03 | |
| Family | ||||
| Bacteroidetes;Barnesiellaceae | 0.37 | .003 | .02 | |
| Bacteroidetes;Odoribacteraceae | 0.36 | .003 | .02 | |
| Bacteroidetes;Paraprevotellaceae | 0.44 | .03 | .06 | |
| Bacteroidetes;Rikenellaceae | 0.30 | .03 | .06 | |
| Firmicutes;Christensenellaceae | 0.45 | .001 | .02 | |
| Firmicutes;Erysipelotrichaceae | −0.16 | .02 | .046 | |
| Firmicutes;Lachnospiraceae | −0.33 | .003 | .02 | |
| Firmicutes;Peptostreptococcaceae | −0.16 | .04 | .07 | |
| Firmicutes;Streptococcaceae | −0.33 | .005 | .02 | |
| Proteobacteria;Enterobacteriaceae | −0.24 | .008 | .03 | |
| Proteobacteria;Pseudomonadaceae | −0.30 | .006 | .02 | |
| Genus | ||||
| Bacteroidetes;Butyricimonas | 0.30 | .02 | .05 | |
| Bacteroidetes;Odoribacter | 0.38 | .01 | .05 | |
| Bacteroidetes;Paraprevotella | 0.39 | .048 | .12 | |
| Bacteroidetes;unclassified | 0.43 | .001 | .02 | |
| Firmicutes;Anaerotruncus | 0.37 | .005 | .04 | |
| Firmicutes;Blautia | −0.27 | .008 | .04 | |
| Firmicutes;Dorea | −0.43 | .002 | .02 | |
| Firmicutes;Eubacterium | −0.04 | .01 | .04 | |
| Firmicutes;Oscillospira | 0.44 | .002 | .02 | |
| Firmicutes;SMB53 | −0.30 | .03 | .08 | |
| Firmicutes;Streptococcus | −0.45 | .001 | .02 | |
| Firmicutes;unclassified | 0.39 | .02 | .05 | |
| Proteobacteria;Erwinia | −0.19 | .03 | .09 | |
| Proteobacteria;Klebsiella | −0.41 | .01 | .04 | |
| Proteobacteria;Pseudomonas | −0.30 | .008 | .04 | |
| Correlation Between Mucosal Microbiota and Breath Methane Concentration | ||||
| Taxon | Spearman’s correlation coefficient | P value | FDR- adjusted P value | |
| Family | ||||
| Firmicutes;Veillonellaceae | 0.47 | .03 | .67 | |
| Genus | ||||
| Bacteroidetes;Cloacibacterium | 0.24 | .03 | .38 | |
| Firmicutes;Dorea | −0.21 | .01 | .38 | |
| Firmicutes;Phascolarctobacterium | 0.44 | .02 | .38 | |
| By Boruta feature selection | ||||
| Bacteroidetes;Bacteroides | −0.01 | NA | NA | |
NA: Not applicable