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Plasma levels of ketamine (15 mg/kg; i.p.) and its metabolites
| 7 days pre-K BL (μM) | 3 days pre-K BL (μM) | 3 hours post-K acute (μM) | 3 hours post-K 10 hr (μM) | 3 days post-K 10 hr (μM) | 7 days post-K 10 hr (μM) | 10 days post-K 10 hr (μM) | |
|---|---|---|---|---|---|---|---|
| K | BLD | BLD | 7.6 ± 1.4 | 10.0 ± 3.9 | BLD | BLD | BLD |
| NK | BLD | BLD | 38.0 ± 4.0 | 105 ± 23 | BLD | BLD | BLD |
| DHNK | BLD | BLD | 7.1 ± 1.0 | 28 ± 5 | BLD | BLD | BLD |
Mean ± SEM; n = 7 – 9; BLD: below limit of detection
