Table 7.
Alcohol intake in relation to LINE-1 methylation colon cancer subtype incidence and subtype heterogeneity evaluations by study design
| Study design [Sample size] | Unconstrained model | Constrained model | ||
|---|---|---|---|---|
| Subtype-specific RR/OR (95% CI); LINE-1 high, medium, low | P value for heterogeneity (categorical, ordinal) | Subtype-specific RR/OR (95% CI); LINE-1 high, medium, low | P value for heterogeneity (categorical, ordinal) | |
| Prospective cohort [268 cases; 47,363 men; 701,119 person- years] | 1.00 (0.79–1.26) | 0.017 0.124 |
1.00 (0.80–1.25) | 0.017 0.109 |
| 1.57 (1.27–1.94) | 1.54 (1.25–1.89) | |||
| 1.36 (1.05–1.77) | 1.36 (1.06–1.76) | |||
| Nested case-control [268 matched sets; 1:2 matching] | 1.01 (0.74–1.39) | 0.083 0.031 |
0.98 (0.73–1.31) | 0.139 0.099 |
| 1.51 (1.07–2.15) | 1.43 (1.07–1.92) | |||
| 1.86 (1.09–3.17) | 1.39 (0.97–1.99) | |||
| Unmatched case-control [268 cases; 533 controls] | 0.96 (0.74–1.24) | 0.014 0.180 |
0.94 (0.72–1.22)* | 0.023 0.169 |
| 1.55 (1.21–1.99) | 1.56 (1.21–2.01)* | |||
| 1.30 (0.96–1.77) | 1.30 (0.95–1.78)* | |||
| Case-case [268 cases] | 1.00 | 0.014 0.097 |
1.00 | 0.016 0.105 |
| 1.68 (1.18–2.39) ** | 1.55 (1.15–2.08)** | |||
| 1.39 (0.95–2.04) ** | 1.32 (0.95–1.84)** | |||
Based on the conditional logistic regression method described in Section 3.3.2.
Ratio of the OR for LINE-1 medium or low colon cancer to the OR for LINE-1 high colon cancer. The following variables were adjusted for in all analyses: current aspirin use (≥2 tablets/week or less), body mass index (kg/m2) (<21, 21–22.9, 23–24.9, 25–29.9, 30+), history of colorectal screening (yes/no), physical activity in metabolic equivalent of tasks (quintiles), history of colorectal polyps (yes/no), family history of colon cancer (yes/no), smoking (pack-years), red meat intake (quintiles), multivitamin use (yes/no), calcium intake (quintiles) and folate intake (quintiles).