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Appl1;Appl2 DKO mice have unaltered Pi3k signaling in vivo. Tissues from thymic T cells (A) and stomach (B) were subjected to immunoblotting using antibodies against the indicated proteins. Levels of phospho-Akt, phospho-Erk, phospho-p38 and phospho-AMPK were compared among the four genotypes. A1KO = Appl1 KO mice; A2KO = Appl2 KO mice.
