Table 1.
Baseline characteristics of African American participants (age 70 or older) enrolled in 1992 and 2001: Participants diagnosed as incident dementia during the course of the follow-up were included in the dementia group.
| 1992 African American Cohort | 2001 African American Cohort | |||||
|---|---|---|---|---|---|---|
| Variables | Dementia (n=191) |
Non-demented (n=1249) |
Overall (n=1440) |
Dementia (n=94) |
Non-demented (n=1741) |
Overall (n=1835) |
| Mean Age (SD) | 78.5 (6.1) | 77.6 (5.9)* | 77.7 (5.9) | 79.4 (6.4) | 77.1 (5.4)* | 77.2 (5.5)# |
| Female, % | 72.8 | 64.4* | 65.5 | 74.5 | 65.0 | 65.5 |
| Years of education (SD) | 9.2 (3.3) | 9.4 (3.1) | 9.4 (3.1) | 10.6 (3.1) | 11.4 (2.6)* | 11.4 (2.7)# |
| Alcohol, % | 28.0 | 39.1* | 37.6 | 33.3 | 38.3 | 38.0 |
| Smoking, % | 50.8 | 64.1* | 62.4 | 41.9 | 56.8* | 56.1# |
| Cognitive score | 29.8 (2.9) | 30.4 (2.4)* | 30.3 (2.5) | 30.2 (2.2) | 30.9 (2.1)* | 30.9 (2.2)# |
| Medical History of | ||||||
| CHD, % | 28.8 | 27.9 | 28.1 | 24.5 | 31.0 | 30.7 |
| Cancer, % | 12.0 | 12.1 | 12.1 | 8.5 | 17.3* | 16.8# |
| Diabetes, % | 18.3 | 25.7* | 24.7 | 28.7 | 29.2 | 29.2# |
| Heart attack, % | 13.1 | 16.1 | 15.7 | 9.6 | 14.2 | 14.0 |
| Hypertension, % | 66.5 | 64.9 | 65.1 | 71.0 | 75.8 | 75.6# |
| Parkinson’s, % | 0.0 | 1.3 | 1.1 | 1.1 | 0.9 | 0.9 |
| Stroke, % | 10.0 | 12.6 | 12.2 | 21.7 | 14.8 | 15.2# |
| Depression, % | 5.8 | 6.5 | 6.4 | 10.9 | 11.0 | 11.0# |
| Medication Use | ||||||
| Antihypertensive, % | 40.3 | 45.3 | 44.7 | 66.3 | 77.5* | 76.9# |
| Anti-diabetic, % | 12.0 | 15.1 | 14.7 | 21.7 | 21.9 | 21.9# |
| Lipid-Lowering medications | 1.6 | 1.5 | 1.5 | 19.6 | 25.2 | 24.9# |
*
: p<0.05 comparing participants with incident dementia to those who remained non-demented within each cohort
#
: p<0.0001 comparing participants between the 1992 cohort and the 2001 cohort