(A) Total number of wheel turns in one-minute bins across the entire 14-day experiment. (B) Wheel turns in one-minute bins across circadian cycles of a 24 hour period, averaged across experiment. (C) Bout analysis, showing (C1) average daily number of running bouts, (C2) average duration of bouts, (C3) average speed of running (turns/min) and (C4) the average inter-bout interval. * p < .05, ** p < .01, *** p < .001, N.S., not significant difference. N=11, WT; N=6, KD.