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. 2015 Dec 1;8(12):1569–1578. doi: 10.1242/dmm.021428

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© 2015. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 2. — Flies expressing long CUG repeats in Drosophila cardiomyocytes have a shortened median survival and increased arrhythmicity. (A) Average percentage of live flies, with the genotypes indicated, versus age (in days). Horizontal dotted line marks the median survival. Whereas control and short-repeat-expressing flies had a similar median survival of 47 and 40.5 days, respectively [GFP, n=40 and CTG(20)×, n=50], long-CUG-expressing flies lived a median of only 25 days [CTG(250)×, n=45). Differences in survival curves were highly significant (P<0.0001, log-rank test). (B,C) Heart period mean (HP, B), and arrhythmia index (AI, C) from flies expressing long and short CUG repeats and two types of control flies (F1 from crosses between the GMH5-Gal4 driver and w⁻ or UAS-GFP). Both parameters are significantly increased in flies expressing long repeats. The bars on the graph show mean values and their standard errors. **P<0.01, ***P<0.001, ns, not significant. (D-G) Representative M-modes (20 s) (D,F), with their respective histogram showing the percentage of beats and their duration (E,G), taken from movies of semi-intact fly hearts expressing long (D,E) or short (F,G) repeats. Red and blue horizontal lines represent the diastolic interval (DI) duration of CUG(250)×- and CUG(20)×-expressing flies, respectively. The systolic interval (SI) and the heart period (HP) length are also indicated in D. The HP histograms, plotted as individual data points (n=21, E; n=29, G), illustrate the variability of the HP within a group of flies expressing long (E) and short (G) repeats.