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. 2015 Dec 1;8(12):1569–1578. doi: 10.1242/dmm.021428

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© 2015. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Pentamidine rescued lifespan, median survival and arrhythmicity in DM1 model flies. (A) The average percentage of live flies, with the genotypes indicated, versus age (in days). Horizontal dotted line marks median survival. Model flies taking pentamidine [CUG(250)× P] had 40 days of median life, in comparison to only 28 days for long (CUG)250×-expressing flies fed with DMSO [CUG(250)× D]. The survival curves of model flies fed with pentamidine and control flies expressing short repeats fed with DMSO [CUG(20)× D] were not statistically different. (B) The heart period (HP) mean was not significantly altered by pentamidine administration, although a clear trend towards reduction was observed, whereas the arrhythmia index (AI) was strongly reduced (C). Graph bars show the mean values and their standard errors. *P<0.05, **P<0.01, ***P<0.001, ns, not significant. (D-G) Representative M-modes (20 s) (D,F) with their corresponding histograms (E, n=25; G, n=30) of percentage of beats of a given duration taken from movies of semi-intact flies expressing long repeats fed either with DMSO (D,E) or with pentamidine (F,G). Red and blue horizontal lines denote the diastolic interval (DI).