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. 2015 Dec 1;8(12):1569–1578. doi: 10.1242/dmm.021428

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© 2015. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 6. — Pentamidine mechanism of action. (A-C) Representative fluorescent confocal images of adult heart cells from long-CUG-expressing flies fed with pentamidine. Combined immunostaining of Muscleblind and CUG RNA FISH showed Muscleblind release (A) and no detectable foci (B) in the nucleus of cardiomyocytes of these flies. (C) Merge of A, B and DAPI; counterstaining of nuclei shows dispersed Mbl localization in nuclei. (D) Graph bar represents average fold changes of CUG(250)× expression in logarithmic scale, calculated by the 2^−ΔΔCt method, and their confidence intervals. Pentamidine did not significantly alter expression level of CUG repeat RNA in model flies. ns, not significant. Scale bar: 10 µm.