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. 2016 Jan 1;9(1):69–79. doi: 10.1242/dmm.021659

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© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 1. — IN inoculation with different NTHi strains produces variation in ME infection rate and bacterial titre, but for NTHi 162 these parameters do not vary over a 10⁴-10⁸ CFU inoculum dose. (A,C) Jbo/+ mice were sampled 7 days after IN inoculation with different NTHi strains; ME infection rates (A) and titres (C) vary with NTHi strain. (B,D) For NTHi 162, ME infection rate (B) and titres (D) were not significantly different when inoculum doses were used over the range of 10⁴-10⁸ CFU. n=11-12 mice per cohort; data are represented as mean±95% CI. Fisher’s exact test in B; one-way ANOVA in D; NS, not significant.