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. 2016 Jan 1;9(1):69–79. doi: 10.1242/dmm.021659

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© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 8. — Azithromycin treatment eliminates NTHi infection. (A,C) Time course of ME infection rate (A) and titre (C) for 8-week-old Jbo/+ mice inoculated with 10⁶ CFU of NTHi 162 (n=11-12 per time point). (B,D) Jbo/+ mice were treated with 100 mg/kg azithromycin (AZM) by oral gavage once a day for 3 days starting on day 4 post-inoculation with 10⁶ CFU of NTHi 162, and sampled at day 7. (B) ME infection rate was significantly reduced in the AZM-treated group. (D) NTHi titre in the vehicle-treated group was 10^5.3 CFU/µl (10^5.1-10^5.4), whereas NTHi were not detected in the AZM-treated group (detection limit 10² CFU/µl); n=15 Jbo/+ per group. Data are represented as mean±95% CI. (B) Fisher’s exact test. (D) One-sample t-test using a hypothetical sample mean of 10² CFU/µl. ***P<0.001.