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. 2015 Oct 2;4(11):1376–1386. doi: 10.1242/bio.012088

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© 2015. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 8. — Summary of functions of Wnt-Foxj1a signaling in LR pattern formation. Wnt/β-catenin signaling regulates Foxj1a expression in KV via Lef1 and Tcf7 binding to the foxj1a regulatory sequence. The Wnt-Foxj1a axis appears to regulate LR asymmetry via at least two mechanisms: the first involves cilia outgrowth that is dependent on the canonical function of Foxj1a in cilia formation, and the second involves expression of charon that requires non-ciliary function of Foxj1a. Yellow highlighting indicates novel discoveries of the study.