Figure 4.

The protective effects of The CB₂ receptor agonist LEI‐101 against cisplatin (Cis)‐induced nephrotoxicity are absent in CB₂R^‐/‐ mice. The renal dysfunction was aggravated in CB₂R^−/− mice compared with CB₂R^+/+ littermates. LEI‐101 alone had no effect on blood urea nitrogen (BUN) and creatinine (CREA) levels compared with the vehicle (Veh)‐treated group and had no protective effect in CB₂R^−/−mice against cisplatin‐induced nephrotoxicity. Results are means ± SEM; n = 6 per group. * P < 0.05, significantly different from vehicle; # P < 0.05, significantly different from cisplatin.