Figure 4.

Concentration–response curves to noradrenaline or phenylephrine (PE) in absence and presence of increasing concentrations of mirabegron (10–100 μM) in rat isolated vas deferens (A), prostate (B), aorta (C) and spleen (D) preparations. (E) The Schild plots for mirabegron in vas deferens, prostate and aorta. (F) Competition for the specific binding of [³H]prazosin by mirabegron in membrane preparations from HEK‐293 cells expressing α_1A‐, α‐ and Δ^1–79α_1D‐adrenoceptors. Data are presented as mean ± SEM (n = 4–6).