Figure 7.

ClC‐3 channels were involved in AngII‐induced cerebrovascular remodelling via ROCK. A. AngII‐induced cerebrovascular remodelling was inhibited in ClC‐3 null and Y27632‐treated mice. Representative pictures showed the morphological characteristics of basilar arteries stained with anti‐α actin. Photographs were taken from control, hypertensive mice, with or without Y27632 treatment, in WT and ClC‐3 null mice. AngII‐induced cerebrovascular remodelling was significantly decreased in ClC‐3 null mice and in Y27632‐treated mice. B. a–d. Bar charts of blood pressure, media thickness, media/lumen ratios and cross‐sectional areas from the experiments. n = 5, *P < 0.05 vs. WT con, #P < 0.05 vs. WT Ang.