Figure 1.

Multiple factors contribute to neuropsychiatric disorder susceptibility. These factors include genetic predisposition, developmental insult, brain injury and natural (or disease-state) aging. Together these factors can influence the molecular, physiological and structural characteristics of the brain. Environmental (or external) factors, such as the demands of life, loss of a loved one or experiencing abuse can also have a negative impact on brain health. Taken together, neuropsychiatric disorder development is extremely cofounded with multiple variables, resulting in individualized trajectories to the same end point: a neuropsychiatric disorder.