Table 2.
Molecular targets that are modulated by (+)-aeroplysinin-1 in endothelial cells.
| Cell Line | Treatment (μM) | Target | Effect | Activity | Reference |
|---|---|---|---|---|---|
| EVLC-2 | 2.5 | MMP-2 | Decrease | Anti-angiogenic | [38] |
| HUVEC | 2.5 | MMP-2 | Decrease | Anti-angiogenic | [38] |
| HUVEC | 10 | MCP-1 | Decrease | Anti-inflammatory | [38] |
| HUVEC | 10 | TSP-1 | Decrease | Anti-inflammatory | [38] |
| HUVEC | 10 | COX-2 | Decrease | Anti-inflammatory | [38] |
| HUVEC | 20 | Il-1α | Decrease | Anti-inflammatory | [38] |
| HUVEC | 20 | MMP-1 | Decrease | Anti-inflammatory | [38] |
| RF-24 | 2.5 | MMP-2 | Decrease | Anti-angiogenic | [38] |
| BAEC | 10 | Cleaved lamin-A | Increase | Apoptogenic | [39] |
| BAEC | 10 | Caspase-2, -3, -8, -9 | Increase | Apoptogenic | [39] |
| BAEC | 10 | Cytochrome C | Increase in cytoplasm | Apoptogenic | [39] |
| HUVEC | 10 | p-Bad | Increase | Apoptogenic | [39] |
| BAEC | 3 | MMP-2 | Decrease | Anti-angiogenic | [40] |
| BAEC | 3 | PA | Decrease | Anti-angiogenic | [40] |
| BAEC | 3 | PAI | Increase | Anti-angiogenic | [40] |
BAEC: bovine aortic endothelial cells, HUVEC: human umbilical vein endothelial cells, EVLC-2: SV40 large T-antigen immortalized human umbilical vein cells; RF-24: papillomavirus 16 E6/E7 immortalized human umbilical vein cells; HMEC: human microvascular endothelial cells.