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. 2015 Dec 22;14(1):1. doi: 10.3390/md14010001

Table 2.

Molecular targets that are modulated by (+)-aeroplysinin-1 in endothelial cells.

Cell Line Treatment (μM) Target Effect Activity Reference
EVLC-2 2.5 MMP-2 Decrease Anti-angiogenic [38]
HUVEC 2.5 MMP-2 Decrease Anti-angiogenic [38]
HUVEC 10 MCP-1 Decrease Anti-inflammatory [38]
HUVEC 10 TSP-1 Decrease Anti-inflammatory [38]
HUVEC 10 COX-2 Decrease Anti-inflammatory [38]
HUVEC 20 Il-1α Decrease Anti-inflammatory [38]
HUVEC 20 MMP-1 Decrease Anti-inflammatory [38]
RF-24 2.5 MMP-2 Decrease Anti-angiogenic [38]
BAEC 10 Cleaved lamin-A Increase Apoptogenic [39]
BAEC 10 Caspase-2, -3, -8, -9 Increase Apoptogenic [39]
BAEC 10 Cytochrome C Increase in cytoplasm Apoptogenic [39]
HUVEC 10 p-Bad Increase Apoptogenic [39]
BAEC 3 MMP-2 Decrease Anti-angiogenic [40]
BAEC 3 PA Decrease Anti-angiogenic [40]
BAEC 3 PAI Increase Anti-angiogenic [40]

BAEC: bovine aortic endothelial cells, HUVEC: human umbilical vein endothelial cells, EVLC-2: SV40 large T-antigen immortalized human umbilical vein cells; RF-24: papillomavirus 16 E6/E7 immortalized human umbilical vein cells; HMEC: human microvascular endothelial cells.