Table 1.
13C- and 1H-NMR Data of N-acetyl-N-demethylmayamycin (1) (in DMSO-d6).
| No. | δC, Type | δH (J = Hz) | HMBC | No. | δC, Type | δH (J = Hz) | HMBC |
|---|---|---|---|---|---|---|---|
| 1 | 155.2, C | 12a | 137.7 a, C | ||||
| 2 | 111.5, CH | 6.64, brs | 1, 4, 12b, 13 | 12b | 115.4, C | ||
| 3 | 141.0, C | 13 | 22.3, CH3 | 2.40, s | 2, 3, 4 | ||
| 4 | 115.4, CH | 7.89, brs | 2, 5, 12b, 13 | 1′ | 71.0, CH | 5.44, dd (12.1, 2.3) | 4a, 5, 6 |
| 4a | 137.6 a, C | 2′ | 36.0, CH2 | 1.86, m; 2.10, 1H, m | 1′, 3′, 4′ | ||
| 5 | 124.2, C | 3′ | 52.5, CH | 3.85, m | 7′ | ||
| 6 | 152.1, C | 4′ | 74.2, CH | 3.20, m | 3′ | ||
| 6a | 117.6, C | 5′ | 77.7, CH | 3.40, dd (9.1, 6.1) | 3′ | ||
| 7 | 191.6, C | 6′ | 18.6, CH3 | 1.27, d (6.1) | 4′, 5′ | ||
| 7a | 115.6, C | 7′ | 169.2, C | ||||
| 8 | 160.2, C | 8′ | 22.3, CH3 | 1.80, s | 7′ | ||
| 9 | 122.9, CH | 7.30, dd (7.5, 1.1) | 7a, 8, 11 | 1-OH | 10.26, s | 1, 2, 12b | |
| 10 | 137.5, CH | 7.76, t (7.5) | 8, 11, 11a | 6-OH | 12.26, s | 5, 6, 6a | |
| 11 | 117.9, CH | 7.43, dd (7.5, 1.1) | 7a, 9, 12 | 8-OH | 11.36, s | 7a, 8, 9 | |
| 11a | 136.6, C | 3′-NH | 7.87, d (8.2) | 3′, 7′ | |||
| 12 | 184.6, C | 4′-OH | 5.02, d (5.1) |
a The data with the same label in each column may be interchanged.