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Inhibitory effects of compounds 1–3 on elastase release and superoxide anion generation by human neutrophils in response to fMet-Leu-Phe/Cytochalastin B.
| Elastase Release | Superoxide Anion | |
|---|---|---|
| Compound | IC50 (μM) a | IC50 (μM) a |
| 1 | 3.32 | 2.33 |
| 2 | >10 | >10 |
| 3 | 2.81 | 2.50 |
a Concentration necessary for 50% inhibition (IC50).
