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. 2016 Jan 9;14(1):15. doi: 10.3390/md14010015

Figure 1.

Figure 1

Figure 1

The oligo Fucoidan inhibited platelet-derived growth factor (PDGF)-stimulated proliferation of airway smooth muscle cells (ASMCs). ASMCs were serum deprivation (0.2% FBS-containing medium) for 48 h, growth-arrested ASMCs were treated with 40-ng/mL rhPDGF-BB or oligo fucoidan (100, 500, or 1000 µg/mL). After incubation for 48 h, the rate of proliferation of cells was assayed by XTT. (a) Growth-arrested cells were treated with 40-ng/mL rhPDGF-BB and oligo fucoidan (100, 500, or 1000 µg/mL) for 24 h, 48 h, or 72 h, the rate of proliferation of cells was assayed by XTT; (b) Growth-arrested cells were treated with 40-ng/mL rhPDGF-BB, 40-ng/mL rhPDGF-BB + 10 nM budesonide, 40-ng/mL rhPDGF-BB + 10 nM fenoterol and 40-ng/mL rhPDGF-BB + combination (10 nM budesonide + 10 nM fenoterol) withot or with different oligo fucoidan (100, 500, or 1000 µg/mL) concentration for 48 h, the rate of proliferation of cells was assayed by XTT.* compare with control group (p < 0.05); # compare with PDGF group (p < 0.05); & compare with PDGF + budesonide group (p < 0.05); + compare with PDGF + fenoterol group (p < 0.05), $ compare with PDGF + budesonide + fenoterol group (p < 0.05); (c) Results are from three individual experiments. One-way ANOVA and post hoc Tukey’s test have been used. p < 0.05 indicated significant differences.