Figure 3.

Oligo fucoidan decreased the PDGF-induced phosphorylation of Akt in ASMCs. Growth-arrested cells were treated with 40-ng/mL rhPDGF-BB or oligo fucoidan (100, 500, or 1000 µg/mL) for 30 and 60 min. Western blot was performed with phosphorylated Akt and Akt antibodies. Normalized signals (Akt phosphorylation/Akt) also were performance. (a) Normalized signals from three independent experiments are presented in the bar charts. * Significantly different from the value obtained with control group, # Significantly different from the value obtained with PDGF group, p < 0.05; (b) One-way ANOVA and post hoc Tukey’s test have been used. p < 0.05 indicated significant differences.