Table 1.
Riboregulator | Type | Environmental influence | Target | Virulence associated process |
---|---|---|---|---|
CsrB/CsrC | Sequestering sRNAs | Carbon | CsrA | Invasion |
RnaG | cis-encoded sRNA | Temperature | icsA | Spread |
RyhB | trans-encoded sRNA | Iron | VirB | Invasion |
5′ UTR ShuA | RNA thermometer | Iron and temperature | ShuA | Iron acquisition from heme |
Each riboregulator described in Shigella has also contributed to virulence of Shigella in some way. The sRNAs seem to effect invasion and spread while the RNA thermometer is important with iron acquisition.