Figure 6.
Effect of isorubijervine and rubijervine on hNaV1.5 channels expressed in HEK293t cells. (A) Inhibition of hNaV1.5 channel currents by 5 µM isorubijervine; (B) concentration-response curves for the inhibition of hNaV1.5 channels by isorubijervine (n = 4); (C) effect of 5 µM isorubijervine on the conductance–voltage (G–V) relationship (dot) and voltage dependence of steady-state inactivation (square); (D) inhibition of hNaV1.5 channel currents by 5 µM rubijervine; (E) concentration-response curves for the inhibition of hNaV1.5 channels by rubijervine (n = 4); (F) effect of rubijervine on the G–V relationship and voltage dependence of the steady-state inactivation (square) of hNaV1.5 channels (n = 5).