Table 1.
Groups of toxic reaction and animal deaths.
| Compounds | Total Number of Mice b | Drug Concentration (mg/kg) | Number of Toxic Symptoms | Number Dead | LD50 (mg/kg) |
|---|---|---|---|---|---|
| Solvent control a | 5 | - | 0 | 0 | - |
| Isorubijervine | 5 | 2 | 5 | 5 | 1.14 ± 0.10 |
| 10 | 1.5 | 10 | 8 | ||
| 10 | 1 | 10 | 4 | ||
| 10 | 0.75 | 4 | 0 | ||
| 10 | 0.5 | 0 | 0 | ||
| Rubijervine | 5 | 7 | 5 | 5 | 1.77 ± 0.20 |
| 10 | 5 | 10 | 8 | ||
| 10 | 2 | 10 | 6 | ||
| 10 | 1.5 | 10 | 2 | ||
| 10 | 1 | 9 | 0 | ||
| 10 | 0.5 | 1 | 0 |
a Menstruum is 40% DMSO in normal saline. b All mice were administered a single dose of the drug in the same volume (100 µL) via tail vein injection.