Table 1.
Author/Year | Total Patient (n) | Type of Study | Type of Cancer/Treatment | Type of Pain | Type of Toxin | Site of Injection | Total Toxin Dose (Unit) | Pain Scale | Outcome |
---|---|---|---|---|---|---|---|---|---|
Van Daele et al. 2002 [11] | 6 | Case series | Head and neck/radiation | Intermittent, tightness, Painful spasms | Toxin A (not specified) | Sternocleidomastoid muscle | 40 | No pain rating scale used | 4 patients demonstrated complete pain relief |
Wittekindt et al. 2006 [9] | 23 | Prospective | Head and neck/surgery | Spontaneous, continuous, burning, shooting, allodynia | AboA | Targeted areas of pain in the neck | 80–240 | Global quality of life scale, scale pain | Pain relief: 13 patients (56.5%) Pain unchanged: 6 patients (26%) Pain increased 4 patients (17.4%) |
Hartl et al. 2008 [12] | 19 | Non-randomized prospective | Head and neck/radiation | Spontaneous, cramps, trismus | AboA and OnaA | masseter | 250 (abo), 50 (ona) |
Trismus-pain questionnaire | All showed significant improvement of overall functional score, muscle cramps and pain |
Mittal et al. 2012 [13] | 7 | Retrospective | Lung, breast, head and neck | Neuropathic, myofascial | OnaA | Affected areas of pain (neck, breast, thorax) | 20–80 | VAS, PGIC scale, quality of life scale | Pain improved in all patients |
Bach et al. 2012 [4] | 9 | Retrospective | Head and neck/radiation and surgery | Contracture | AboA | Sternocleidomastoid | 100–800 | Functional disability scales for neck pain | pain and neck motion improvement (7 patients), pain relief but no neck motion improvement (1 patient), No improvement (1 patient) |
Dessy et al. 2014 [14] | 1 | Case report | Breast/surgery | Numbness, pins, burning | OnaA | Pectoralis major | 50 | Tinel’s sign and pain relief reported by patient | Complete pain relief, able to lift and rotate the arms, return to a normal personal and professional life |
AboA = Abobotulinum toxin A, OnaA = Onabotulinum toxin A.