Table 1.

Previous studies with OnaA and AboA for treatment of focal post-surgical radiation pain in cancer patients.

Author/Year	Total Patient (n)	Type of Study	Type of Cancer/Treatment	Type of Pain	Type of Toxin	Site of Injection	Total Toxin Dose (Unit)	Pain Scale	Outcome
Van Daele et al. 2002 [11]	6	Case series	Head and neck/radiation	Intermittent, tightness, Painful spasms	Toxin A (not specified)	Sternocleidomastoid muscle	40	No pain rating scale used	4 patients demonstrated complete pain relief
Wittekindt et al. 2006 [9]	23	Prospective	Head and neck/surgery	Spontaneous, continuous, burning, shooting, allodynia	AboA	Targeted areas of pain in the neck	80–240	Global quality of life scale, scale pain	Pain relief: 13 patients (56.5%) Pain unchanged: 6 patients (26%) Pain increased 4 patients (17.4%)
Hartl et al. 2008 [12]	19	Non-randomized prospective	Head and neck/radiation	Spontaneous, cramps, trismus	AboA and OnaA	masseter	250 (abo), 50 (ona)	Trismus-pain questionnaire	All showed significant improvement of overall functional score, muscle cramps and pain
Mittal et al. 2012 [13]	7	Retrospective	Lung, breast, head and neck	Neuropathic, myofascial	OnaA	Affected areas of pain (neck, breast, thorax)	20–80	VAS, PGIC scale, quality of life scale	Pain improved in all patients
Bach et al. 2012 [4]	9	Retrospective	Head and neck/radiation and surgery	Contracture	AboA	Sternocleidomastoid	100–800	Functional disability scales for neck pain	pain and neck motion improvement (7 patients), pain relief but no neck motion improvement (1 patient), No improvement (1 patient)
Dessy et al. 2014 [14]	1	Case report	Breast/surgery	Numbness, pins, burning	OnaA	Pectoralis major	50	Tinel’s sign and pain relief reported by patient	Complete pain relief, able to lift and rotate the arms, return to a normal personal and professional life

AboA = Abobotulinum toxin A, OnaA = Onabotulinum toxin A.