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. 2015 Dec 29;8(1):8. doi: 10.3390/v8010008

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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HCMV-induced TNKS accumulation correlates with decreased β-catenin. Western blot showing levels of Wnt proteins (TNKS, Axin1, β-catenin) in infected HFFs (A) and IST-1 (B) cells. XAV939 (0.1 and 1 μM) and Salinomycin (0.1 μM) were used as modulators of Wnt. TNKS accumulates in response to HCMV infection and β-catenin is reduced upon infection; (C) and (D) show the quantification of (A) and (B) respectively from three representative experiments. Data plotted is mean ± standard error, SE. Lane numbers in Western blot figures correspond to lane numbers in quantification plots. * indicates p value < 0.05, ** indicates p < 0.01, and *** indicates p < 0.001, for changes in β-catenin.

HCMV-induced TNKS accumulation correlates with decreased β-catenin. Western blot showing levels of Wnt proteins (TNKS, Axin1, β-catenin) in infected HFFs (A) and IST-1 (B) cells. XAV939 (0.1 and 1 μM) and Salinomycin (0.1 μM) were used as modulators of Wnt. TNKS accumulates in response to HCMV infection and β-catenin is reduced upon infection; (C) and (D) show the quantification of (A) and (B) respectively from three representative experiments. Data plotted is mean ± standard error, SE. Lane numbers in Western blot figures correspond to lane numbers in quantification plots. * indicates p value < 0.05, ** indicates p < 0.01, and *** indicates p < 0.001, for changes in β-catenin.