Figure 5.

Comparison of the telomeric repeat structure between 12 CiHHV-6A integrated at chromosome 17p subtelomere and at different chromosomes 18 and 10. The repeat structures were determined and grouped into (a) In vivo virus genome integration sites at 17p telomeric repeat structure (including the 12 integration sites characterized here); (b) in vivo human 17p telomeric repeat structure at the integration site without virus genome; (c) in vitro derived human virus genome integration sites; (d) in vivo virus genome integration sites at chromosome 10q and (e) in viro, the perfect telomeric repeats in the exogenous virus towards the right termini prior to chromosomal integration. Imperfect repeats derived from the human subtelomeric region are shaded. The length differ in the number of perfect telomeric repeats in the center as shown. Comparisons are shown to two previously described integration sites at 17p with similar structure as well as to the distinct integration site in chromosome 10 and the in vitro integration sites at chromosome 18. Of the 12 integration sites at 17p characterized here, the largest 5055, has accession number TBA. Two previous HHV-6A 17p integration sites: HGDP0628 [10], GU784872 [6]; Chromosome 17 subtelomere, complete sequence, genbank AC240565.4; Chromosome 17 telomere adjacent genomic sequence, genbank DQ355024.2.