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. 2016 Jan 27;6:19914. doi: 10.1038/srep19914

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Inhibition of LC3 attenuates melanin synthesis and tyrosinase activity in melanocytes. Melan-a cells were transfected with specific siRNAs for LC3, beclin-1, ATG5, or control siRNA for 24 h and were analyzed by Western blotting after autophagy induction (a,b). Quantification of melanin (c) and tyrosinase activity (d) was performed for each transfected cell line. Results shown are the mean of three independent experiments ± SD. *P < 0.05 versus untreated controls.