Table 4.
Hepatic gene expression in the offspring of dams fed a control, high-protein or high-prebiotic fiber diet during pregnancy and lactation and then re-matched to their respective diets in adulthood.
| Diet Group | p (2-Way ANOVA) | ||||||
|---|---|---|---|---|---|---|---|
| Sex | HP1 | HF1 | C1 | Diet | Sex | Diet × Sex | |
| SREBP-1c | M | 5.5 ± 0.73 | 2.6 ± 0.7 | 4.6 ± 0.67 | 0.002 | 0.002 | 0.143 |
| F | 4.0 ± 0.66 | 2.1 ± 0.47 | 1.7 ± 0.53 | ||||
| ACC | M | 13.3 ± 2.0 | 10.9 ± 2.0 | 15.0 ± 1.6 | 0.032 | 0.553 | 0.097 |
| F | 18.9 ± 3.1 | 10.6 ± 1.2 | 12.6 ± 1.3 | ||||
| FAS | M | 6.8 ± 2.0 | 4.7 ± 1.1 | 4.0 ± 0.74 | 0.002 | 0.001 | 0.124 |
| F | 18.2 ± 3.1 | 13.0 ± 1.9 | 8.2 ± 0.92 | ||||
| PGC1α | M | 88.9 ± 19.6 y | 45.9 ± 9.8 x | 24.1 ± 5.8 x | 0.001 | 0.064 | 0.972 |
| F | 110.9 ± 21.1 y | 62.5 ± 13.6 x | 45.7 ± 6.4 x | ||||
| Glucose-6-Phosphatase | M | 23.6 ± 5.5 x | 19.5 ± 3.8 x,y | 17.1 ± 2.7 x,y | 0.001 | 0.031 | 0.014 |
| F | 43.6 ± 4.4 y | 16.7 ± 2.9 x | 20.5 ± 2.3 x | ||||
| AMPKα1 | M | 16.5 ± 1.6 | 11.7 ± .9 | 10.7 ± 1.4 | 0.006 | 0.587 | 0.121 |
| F | 16.2 ± 2.8 | 9.7 ± 1.8 | 15.2 ± 1.0 | ||||
C1, offspring of control dams re-matched to control; HP1, offspring of high protein (HP) dams re-matched to HP; HF1, offspring of high prebiotic fibre (HF) dams re-matched to HF; SREBP1c, sterol regulatory element-binding protein-1c; M, male; F, female; ACC, acetyl-CoA carboxylase; FAS, fatty acid synthase; PGC1α, Peroxisome proliferator-activated receptor gamma coactivator-1-alpha; AMPKα1, AMP-activated protein kinase alpha-1. Values are means ± SEM, n = 10 per group except n = 4 for group H. Values with different letters are significantly different from each other (p < 0.05).