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. 2016 Jan 18;5(1):e185. doi: 10.1038/oncsis.2015.47

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Copyright © 2016 Macmillan Publishers Limited

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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PTX resistance increases CSCs traits in A549. (a) Morphology of A549/PTX cells. (b) Invasion assay of A549 and A549/PTX cells. Images were captured at a magnification of × 200. Percentage of relative invasion in A549 and A549/PTX cells. (c) Expression level of EMT markers in A549 and A549/PTX cells. (d) Sphere formation in the A549 and A549/PTX cells cultured for 10 days (tight, spherical, non-adherent masses >100 μm in diameter; magnification, × 40). Bar represents 100 microns. Sphere formation efficiency=colonies/input cells × 100%. (e) FACS analysis of ALDH-positive cells in A549 and A549/PTX cells. (f) Expression level of stemness genes and (g) survival factors in A549 and A549/PTX cells. Data are the mean±s.e.m. (n=5) *P<0.05 and **P<0.01.