Figure 6. Promotion of Ad early gene expression by TNF-α stimulation in mouse liver.

(A,B) C57BL/6 mice were intravenously administered 10⁹ IFU of WT-Ad (A) or Adv-CALuc (B), followed by intravenous administration of recombinant mTNF-α at 0.5 mg/mouse. Twenty-four hours after the administration, the E1A, E2, E3, and E4 mRNA levels in the mouse liver were determined by quantitative RT-PCR. These data are expressed as the means ± S.E. (n = 5–6). *p < 0.05, **p < 0.01, ***p < 0.001.