Table 1.

Key Components of CRA

Focus on multiple stressors Inclusion of both chemical and nonchemical (e.g., biological, radiological, physical, psychological, work life, lifestyle) stressors Assessment of aggregate exposures and risks (i.e., exposure to a single stressor by multiple routes) Assessment of combined risks for common effects (e.g., chemicals or stressors that have a common mechanism of toxicity) Population-based focus (i.e., assessment starts with the receptors or populations of interest and then determines which chemicals, stressors, or other risk factors are affecting them)